Nathan L. Collie

Office phone: 806-742-2726

Cell Biology Web Site

Associate Professor. Comparative Endocrinology

Ph.D., Zoology, University of California at Berkeley (1984)
M.A., Zoology, University of California at Berkeley (1981)
B.S. (summa cum laude), Zoology, Texas Tech University (1977)

Research interests.   My laboratory currently investigates three primary research problems, all centered around the unifying theme of membrane transport and its regulation in cells. The first problem concerns the hormonal control and intracellular signaling mechanisms that regulate the intestinal transport of nutrients (e.g., sugars and amino acids) and its relationship to diabetes mellitus. A second problem is how do different cell types in breast tissue become resistant to the anti-tumor drugs, such as Taxol. Our focus is understanding how Taxol crosses the plasma membrane and how normal and tumor breast cells differ in their Taxol transport mechanisms. The third problem concerns the mechanism by which perchlorate (an environmental contaminant found near military installations) disrupts thyroid hormone synthesis in amphibians. As in mammals, perchlorate most likely inhibits the sodium/iodide symporter in thyroid and, perhaps, in extrathyroidal tissues.

Here is an expanded version of my research interests.

Selected Publications.

Collie, N. L., J. H. Walsh,, H. C. Wong, J. E. Shively, T. D. Lee, M. Davis, and J. R. Reeve, Jr. 1994. Purification and sequence of rat oxyntomodulin. Proc. Natl. Acad. Sci. (U.S.A.) 91: 9362-9366.

Collie, N.L. 1995. Hormonal regulation of intestinal nutrient absorption in vertebrates. Amer. Zool 35: 474- 482.

Collie, N.L. and Ferraris, R.P. 1995. Nutrient fluxes and regulation in fish intestine. In Biochemistry and Molecular Biology of Fishes, eds. P.W. Hochachka and T.P. Mommsen, Vol. 4. Amsterdam, Elsevier. 221-239.

Collie, N.L., Zhu, Z., Jordan, S., and Reeve, J.R.,Jr. 1997. Oxyntomodulin stimulates intestinal glucose uptake in rats. Gastroenterology 112: 1961-1970.